Toxicology & Safety Pharmacology

In Vivo Toxicology:

Safety Pharmacology:

• Cardiovascular
  • In vivo radiotelemetry
    • Non-human primate
    • Canine
    • Rat
  • In vitro
    • hERG
    • Multicellular preparations
• Central nervous system
  • Irwin
  • Figure-eight maze
  • Cognition (water maze and passive avoidance)
  • FOB
    • Non-human primate
    • Rodent
  • Respiratory
    • Plethysmography
    • Blood gas analysis

 

Pharmacokinetics (TK):

• Radiolabeled/non-radiolabeled
• Mass balance/excretions
  • Non-human primate
  • Canine
  • Rodent

Toxicology:

• Acute/subacute/chronic
  • Non-human primate
  • Canine
  • Rodent
• Carcinogenicity
• DART
  • One or two generation
  • Developmental neurotoxicity
  • Fertility and embryonic development

 

Pathology:

• Necropsy
• Histology
• Histopathology
• Clinical chemistry
• Hematology

Pharmacology, ADME

Cardiovascular:

• Drug-eluting stents
• Thoracic surgery
• Coronary and peripheral stents/vascular devices
• Cardiac device implantation
• PFO screening and device evaluation

 

Orthopedics:

• Joint/cartilage models
• Spine models
• Bone repair models
• Models of osteopenia and trabecular plate performation

 

Surgical Models:

• Surgical product modeling
• Cannulation, vascular access point, medical device
• Thoracic, abdominal, vascular or orthopedic surgery models
  • Sheep
  • Swine
  • Canine
• Osteoarthritis models
  • Canine
  • Rabbit
  • Guinea pig
• Cardiac bypass capabilities
  • Sheep
  • Swine
  • Canine
• Biomaterial and chemotherapy implants
• Chronic vascular and duodenal access port implanted animals
• Drug delivery
• Cardiovascular models
• Dermal hypersensitivity testing
  • Swine
• Atherosclerosis
  • Swine
  • Rabbit
• Pharmacokinetic studies
  • Canine
  • Swine
  • Rabbit
  • Rodent

 

General Capabilities:

• Pharmacokinetics studies
• Excellent cost effective pharmacokinetics screening
• Animal model development
• Toxicology (non GLP)
• Experimental surgery
  • Biomaterial implants
  • Orthopedic models
  • Cardiovascular models
• Efficacy studies
• Polyclonal antibody production
• Ocular studies, including ocular toxicology

 

Specialized Capabilities:

• State-of-the-art veterinary anesthesia and intra-operative physiologic monitoring
• Endoscopy and arthroscopic surgical equipment
• State-of-the-art electrosurgery equipment including vessel sealing
• Orthopedic research diagnostic capabilities include force plate testing and data analysis
• Top diagnostic imaging including radiography, ultrasound and color flow Doppler imaging, fluoroscopy, CT scanning, MRI, and dual energy x-ray absorptiometry
• Heart/lung bypass machine
• Intra-operative radiation therapy

Laboratories:

• Pre-Clinical Research Services
• Xenometrics