PhoenixBio

PhoenixBio, of Hiroshima, Japan, are the producers of the PXB-mouse.  PXB-mice are Chimeric mice with a healthy and functional liver that has been 70 to 90 percent repopulated by human hepatocytes. PhoenixBio produces them by transplanting human hepatocytes to immunodeficient mice that have liver disease (uPA/SCID).

• PXB-mice exhibit normal histological structures in the liver and secrete human Albumin making them an excellent animal model for PK studies.
  


• PhoenixBio has the ability to run study services requiring the use of radioisotopes, or to be performed in compliance with the GLP-standard at the research facilities of their strategic partner making PXB-mice an excellent candidate for Metabolism with Radioactivity studies.
  
  
• The expression and activity of human metabolic enzymes and transporters, and the secretion of human type bile acids in PXB-mouse liver, has been scientifically confirmed and the PXB-mice have also been successfully infected with hepatitis B and C viruses. 

For more information about PhoenixBio and their PXB-mice, please visit their website at http://phoenixbio.co.jp/en.