Downloads
- DTEx™ Gene Expression Analysis
- Serial CSF and Plasma Collection
- NoAb CSF-ISSX08 Poster
- Quantitative Microdialysis
- Cytochrome P-450 Induction
- Cytochrome P-450 Inhibition Studies
- JPBA SPME In Vivo in Rats
- Metabolic Stability/Microsomes
- Metabolic Stability/Hepatocytes
- Discovery Services
- Cytotoxicity Studies
- Cell Permeability
- Plasma Protein Binding Assay
- Canulated Mouse PK
- BCRP Sales Sheet
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Get Acrobat Reader FREENoAb BioDiscoveries, Inc.
NoAb BioDiscoveries, Inc. (NoAb), of Ontario, Canada, provides comprehensive non-GLP Discovery DMPK services. The primary focus at NoAb is in vivo PK studies using advanced surgical models and in vitro ADMET testing, for Lead Candidate Optimization (LCO).
In Vivo PK studies with serial sample collection are conducted in:
- Cannulated Mice
- Rats
- Hamsters
- Guinea Pigs
Services used to investigate BBB Penetration:
- In Vitro Rat Brain Endothelial Cell Permeability
- Brain Free Fraction Determination
- In Vivo Serial Cerebrospinal Fluid Collection in Freely Moving Rats
- In Vivo Intracerebral Microdialysis in Freely Moving Rats
The In Vitro ADMET capabilities include:
- Cell Permeability
- Plasma Protein Binding
- Activity and Gene Expression Based Cytochrome P450 Inhibition and Induction Studies According to FDA Recommended Guidelines
- Pgp
- Metabolic Stability
- Cytotoxicity Studies
- Time Dependent CYP Inhibition
Bioanalytical services including metabolite profiling utilizing LC-MS/MS are also offered.
In addition, NoAb provides gene expression analysis using DTEx™, a proprietary microarray-based technology that allows investigators to simultaneously survey the gene expression levels of over 140 ADME associated genes.
Click here for BBB Toolbox
Click here for In Vivo Publications
Click here for In Vitro Publications
Click here for Bioanalytical Publications
