The Flourosome Company

The Fluorosome Company, of Worcester, MA,  offers an innovative P-glycoprotein inhibition assay, Fluorosome®-trans-pgp. This assay employs the novel Fluorosome® platform for the testing of drug efflux transporters. It is highly specific and provides superior, efficient, and cost-effective P-glycoprotein/drug interaction determinations.

Fluorosome®-trans-pgp Inhibiton Assay Advantages are:

• Specific: Fluorosome®-trans-pgp contains only the P-glycoprotein transporter
• Cell-free System: No medium containing drug-binding serum proteins used as with cell-based assays
• Multiwell Plate Format: 96-384 well plates
• Dynamic Range: ICsodeterminations over a concentration range of >1000
• No Special Sample Requirements: Non-compound specific - no radiolabel, UV or LC-MS

The Fluorosome Company offers:

P-glycoprotein inhibition testing

Standard testing protocols available as:

• Assays at selected compound concentrations
• 3-point assays, e.g.,100,10,1 pM concentrations
• Multipoint IC50 determinations
• Custom testing assays designed to meet your specific needs

Your own in-house Pgp inhibition testing

Fluorosome-trans-pgp reagent:

• Requires only an injecting fluorescence plate reader
• Rapid and simple, i.e., a7 point IC50 can be completed in 6 minutes
• Fully amenable to robotics

www.fluorosome.com