Drug Metabolism & Pharmacokinetics

In Vitro Studies 

ADME Testing Services 

• Cell permeability (Caco-2 and MDCK)
• Metabolic stability (hepatocytes, microsomes, S9 fractions, homogenate)
• Human, non-human primate, canine, rodent
• Cytochrome P-450 subtypes inhibition/induction
• Plasma protein binding equilibrium dialysis
• Metabolite profiling
• DTEx™ - Proprietary technology for Drug Transporter Evaluation
  • ABC transporters – human and rodent
  • Human and rodent P-450
  • Drug-drug interaction
  • Hepatocyte quality control
• Cytotoxicity assays

 

In Vivo Studies 

PK/TK and Radiolabeled ADME Studies 

• Blood Brain Barrier – serial CSF collection (rodent)
• Single point CSF dog and NHP
• Screening and definitive GLP pharmacokinetic studies
• Tissue distribution, excretion and mass balance studies, expired air
• Microdialysis (rodent)

Species:

• Non-human primate
• Sheep
• Swine
• Canine
• Lab animals (rabbit, guinea pig, rodent)
• Cannulated rat, jugular portal vein, bile duct

Bioanalytical Support 

• Method development/validation
• Screening PK support
• Metabolite profiling
• LC/M/MS; GC/MS; LC/radiochemical detection

 

Laboratories

• NoAb/BioDiscoveries, Inc.
• Pre-Clinical Research Services
• Xenometrics